Lijst van 3FM Megahits in 2021
Deze hits waren in 2021 3FM Megahit op NPO 3FM:
| Nr. | Week | Artiest | Titel |
|---|---|---|---|
| 1382 | Week 1 | YUNGBLUD & Machine Gun Kelly | Acting Like That |
| 1383 | Week 2 | Harry Styles | Treat People with Kindness |
| 1384 | Week 3 | Froukje | Onbezonnen |
| 1385 | Week 4 | Royal Blood | Typhoons |
| 1386 | Week 5 | Son Mieux | 1992 |
| - | Week 6 | Geen 3FM Megahit in verband met de Zeroes Request-week | |
| 1387 | Week 7 | Arlo Parks | Caroline |
| 1388 | Week 8 | Ben Howard | What A Day |
| 1389 | Week 9 | EUT | What Gives You The Kicks |
| 1390 | Week 10 | Silk Sonic | Leave The Door Open |
| 1391 | Week 11 | Fred Again & The Blessed Madonna | Marea (We’ve Lost Dancing) |
| 1392 | Week 12 | London Grammar | How Does It Feel |
| 1393 | Week 13 | Chef'Special | Afraid of the Dark |
| 1394 | Week 14 | Girl In Red | Serotonin |
| 1395 | Week 15 | Twenty One Pilots | Shy Away |
| 1396 | Week 16 | Years & Years | Starstruck |
| 1397 | Week 17 | Eefje de Visser | Storm |
| 1398 | Week 18 | Billie Eilish | Your Power |
| 1399 | Week 19 | Coldplay | Higher Power |
| 1400 | Week 20 | Son Mieux | Drive |
| 1401 | Week 21 | Olivia Rodrigo | Good 4 U |
| 1402 | Week 22 | Wolf Alice | Smile |
| - | Week 23 | Geen 3FM Megahit in verband met de Festival Top 999 | |
| 1403 | Week 24 | S10 | Adem Je In |
| 1404 | Week 25 | Lorde | Solar Power |
| 1405 | Week 26 | Antoon | Hyperventilatie |
| 1405 | Week 27 | Imagine Dragons | Wrecked |
| 1406 | Week 28 | Shouse | Love Tonight |
| 1407 | Week 29 | Sam Fender | Seventeen Going Under |
| 1408 | Week 30 | Swedish House Mafia, Ty Dolla Sign & 070 Shake | Lifetime |
| 1409 | Week 31 | Silk Sonic | Skate |
| 1410 | Week 32 | The Weeknd | Take My Breath |
| 1411 | Week 33 | Jett Rebel | Behave |
| 1412 | Week 34 | The Vaccines | Alone Star |
| 1413 | Week 35 | The Killers & Phoebe Bridgers | Runaway Horses |
| 1414 | Week 36 | Rag'n'Bone Man | Alone (Nothing But Thieves Remix) |
| 1415 | Week 37 | Rondé | Hard To Say Goodbye |
| - | Week 38 | Geen 3FM Megahit in verband met de Top 999 van deze Eeuw | |
| 1416 | Week 39 | Lil Nas X | That's What I Want |
| 1417 | Week 40 | The War On Drugs & Lucius | I Don't Live Here Anymore |
| 1418 | Week 41 | Bazart & S10 | Onderweg |
| 1419 | Week 42 | Stromae | Santé |
| 1420 | Week 43 | Swedish House Mafia & The Weeknd | Moth To A Flame |
| 1421 | Week 44 | Son Mieux | Dancing At The Doors Of Heaven |
| 1422 | Week 45 | De Staat | Numbers Up |
| 1423 | Week 46 | Acraze & Cherish | Do It To It |
| 1424 | Week 47 | MEAU | Dat Heb Jij Gedaan |
| 1425 | Week 48 | Foals | Wake Me Up |
| 1426 | Week 49 | Ewan McVicar | Tell Me Something Good |
| 1427 | Week 50 | Son Mieux | The Mustard Seed |
| - | Week 51
Week 52 |
Geen 3FM Megahit in verband met de 3FM Serious Request-week en de Top Serious Request | |
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